Clindamycin Phosphate Impurity Standards

Clindamycin Phosphate impurity reference standards are used by pharmaceutical quality-control laboratories, contract research organisations, and generic drug manufacturers to identify, quantify, and control Clindamycin Phosphate-related impurities during analytical method development, method validation, and regulatory filing. As a lincosamide antibiotic ester, Clindamycin Phosphate requires precise characterisation of its process impurities, degradation products, and related substances to meet European Pharmacopoeia (EP), United States Pharmacopeia (USP), and British Pharmacopoeia (BP) monograph requirements. Allmpus Laboratories manufactures and supplies a comprehensive library of Clindamycin Phosphate impurity standards, each provided with a Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS). All products are held in-stock for rapid dispatch and are suitable for use in ANDA and DMF regulatory submissions.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CLINDAMYCIN 2-PHOSPHATE SULFOXIDE | MIXTURE OF DIASTEREOMERS

Chemical Name: 7-Chloro-1,6,7,8-tetradeoxy-6-[[[(2S,4R)...

CAS No:
1228573-90-7

Molecular Formula: C18H34ClN2O9PS

Molecular Weight: 520.96

CAT No:
ALL-C03699

Keywords: SMILES string - C[C@H](Cl)[C@@]([C@@]([C...

Inventory Status:IN STOCK/03-242

COA MSDS

CLINDAMYCIN B 3-PHOSPHATE

Chemical Name: (2R,3S,4S,5R,6R)-2-((1S,2S)-2-Chloro-1-(...

CAS No:
N.A

Molecular Formula: C17H32ClN2O8PS

Molecular Weight: 490.9

CAT No:
ALL-C04909

Keywords: CLINDAMYCIN B 3-PHOSPHATE

Inventory Status:IN STOCK/03-256

COA MSDS

CLINDAMYCIN PHOSPHATE

Chemical Name: Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,...

CAS No:
24729-96-2

Molecular Formula: C18H34ClN2O8PS

Molecular Weight: 504.96

CAT No:
ALL-CO6643

Keywords: SMILES string - C[C@H](Cl)[C@@]([C@@]([C...

Inventory Status:IN STOCK/03-243

COA MSDS

CLINDAMYCIN PHOSPHATE EP IMPURITY A

Chemical Name: Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl...

CAS No:
154-21-2

Molecular Formula: C18H34N2O6S

Molecular Weight: 406.54

CAT No:
ALL-C03694

Keywords: Clindamycin EP Impurity A

Inventory Status:IN STOCK/03-240

COA MSDS

CLINDAMYCIN PHOSPHATE EP IMPURITY B

Chemical Name: Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,...

CAS No:
54887-31-9

Molecular Formula: C17H32ClN2O8PS

Molecular Weight: 490.94

CAT No:
ALL-C07170

Keywords: SMILES string - C[C@@](Cl)([H])[C@](NC([...

Inventory Status:IN STOCK/03-244

COA MSDS

CLINDAMYCIN PHOSPHATE EP IMPURITY C

Chemical Name: Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,...

CAS No:
28708-34-1

Molecular Formula: C18H34ClN2O8PS

Molecular Weight: 504.96

CAT No:
ALL-C03545

Keywords: SMILES string - CN(C[C@@](CCC)([H])C1)[C...

Inventory Status:IN STOCK/03-245

COA MSDS

CLINDAMYCIN PHOSPHATE EP IMPURITY D

Chemical Name: Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,...

CAS No:
54887-30-8

Molecular Formula: C18H34ClN2O8PS

Molecular Weight: 504.96

CAT No:
ALL-C03564

Keywords: SMILES string - CN(C[C@@](CCC)([H])C1)[C...

Inventory Status:IN STOCK/03-246

COA MSDS

CLINDAMYCIN PHOSPHATE EP IMPURITY E

Chemical Name: Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,...

CAS No:
21462-39-5 (HCl) / 18323-44-9 (base)

Molecular Formula: C18H34Cl2N2O5S (HCl salt)

Molecular Weight: 461.44

CAT No:
ALL-C03695

Keywords: SMILES string - C[C@H](Cl)[C@@]([C@@]([C...

Inventory Status:IN STOCK/03-241

COA MSDS

CLINDAMYCIN PHOSPHATE EP IMPURITY F I LINCOMYCIN 2-PHOSPHATE

Chemical Name: Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl...

CAS No:
27480-30-4

Molecular Formula: C18H35N2O9PS

Molecular Weight: 486.52

CAT No:
ALL-C03696

Keywords: SMILES string - CN(C[C@@](CCC)([H])C1)[C...

Inventory Status:IN STOCK/03-239

COA MSDS

CLINDAMYCIN PHOSPHATE EP IMPURITY G

Chemical Name: Methyl 6,8-dideoxy-2,4-O-(hydroxyphospho...

CAS No:
N. A

Molecular Formula: C18H33N2O8PS

Molecular Weight: 468.50

CAT No:
ALL-CLI-1171

Keywords: SMILES string - CN1[C@H](C(N[C@]([C@@](C...

Inventory Status:IN STOCK/03-247

COA MSDS

CLINDAMYCIN PHOSPHATE EP IMPURITY H

Chemical Name: Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,...

CAS No:
N. A

Molecular Formula: C18H35ClN2O11P2S

Molecular Weight: 584.94

CAT No:
ALL-C03869

Keywords: SMILES string - CS[C@@H]1[C@H](OP(O)(O)=...

Inventory Status:IN STOCK/03-248

COA MSDS

CLINDAMYCIN PHOSPHATE EP IMPURITY I

Chemical Name: Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,...

CAS No:
1309048-48-3

Molecular Formula: C18H35ClN2O11P2S

Molecular Weight: 584.94

CAT No:
ALL-C03868

Keywords: SMILES string - CS[C@@H]1[C@H](OP(O)(O)=...

Inventory Status:IN STOCK/03-249

COA MSDS

CLINDAMYCIN PHOSPHATE EP IMPURITY J

Chemical Name: Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S)...

CAS No:
1309349-64-1

Molecular Formula: C18H32ClN2O8PS

Molecular Weight: 502.95

CAT No:
ALL-CLI-1174

Keywords: SMILES string - C[C@H](Cl)[C@@]([C@@]([C...

Inventory Status:IN STOCK/03-250

COA MSDS

CLINDAMYCIN PHOSPHATE EP IMPURITY K

Chemical Name: 2,2'-Oxybis(hydroxyphosphoryl)bis[m...

CAS No:
N. A

Molecular Formula: C36H66Cl2N4O15P2S2

Molecular Weight: 991.91

CAT No:
ALL-C08656

Keywords: SMILES string - CS[C@@H]1[C@H](OP(O)(OP...

Inventory Status:IN STOCK/03-251

COA MSDS

CLINDAMYCIN PHOSPHATE EP IMPURITY L / 7-EPI-CLINDAMYCIN PHOSPHATE

Chemical Name: Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,...

CAS No:
620181-05-7

Molecular Formula: C18H34ClN2O8PS

Molecular Weight: 504.96

CAT No:
ALL-C03361

Keywords: SMILES string - CS[C@@H]1[C@H](OP(O)(O)=...

Inventory Status:IN STOCK/03-252

COA MSDS

CLINDAMYCIN PHOSPHATE IMPURITY 1 (R-ISOMER)

Chemical Name: [(2R,3R,4S,5R,6R)-6-((1S,2S)-2-chloro-1-...

CAS No:
N.A

Molecular Formula: C18H34ClN2O9PS

Molecular Weight: 520.96

CAT No:
ALL-C03698

Keywords: SMILES string - [H][C@]1([C@]([C@@H](Cl)...

Inventory Status:IN STOCK/03-254

COA MSDS

CLINDAMYCIN PHOSPHATE IMPURITY 3 (S-ISOMER)

Chemical Name: [(2R,3R,4S,5R,6R)-64(1S,2S)-2-chloro-1-{...

CAS No:
N.A

Molecular Formula: C18H34ClN2O9PS

Molecular Weight: 521.0

CAT No:
ALL-C03697

Keywords: SMILES string - O=P(O)(O[C@H]1[C@H]([S@]...

Inventory Status:IN STOCK/03-253

COA MSDS

ISOPROPYLIDENE CLINDAMYCIN PHOSPHATE

Chemical Name: (3aS,4R,6R,7R,7aS)-4-((1S,2S)-2-Chloro-1...

CAS No:
N.A

Molecular Formula: C21H38ClN2O8PS

Molecular Weight: 545.0

CAT No:
ALL-C03406

Keywords: SMILES string - C[C@H](Cl)[C@@]([C@]1([H...

Inventory Status:IN STOCK/03-806

COA MSDS

Key Clindamycin Phosphate Impurity Variants

Clindamycin Phosphate EP Impurity B (Clindamycin B 2 — Phosphate, CAS 54887-31-9)-a structural variant phosphorylated at the 2-position, listed in the Ph. Eur. monograph
Clindamycin Phosphate EP Impurity C (Clindamycin 3 — Phosphate, CAS 28708-34-1)-a positional isomer with phosphorylation at the 3-hydroxyl instead of the intended 2-position
Clindamycin Phosphate EP Impurity D (Clindamycin 4 — Phosphate, CAS 54887-30-8)-a further positional isomer arising from phosphorylation at the 4-hydroxyl group
Clindamycin Phosphate EP Impurity K (Diclindamycin pyrophosphate) — a pyrophosphate dimer impurity formed through condensation of two clindamycin phosphate molecules
Clindamycin Phosphate EP Impurity L (7 — Epiclindamycin 2-phosphate, CAS 620181-05-7)-a stereochemical epimer at the 7-position, phosphorylated at the 2-position
Additional EP — lettered impurities (Impurity A through J) and sulfoxide diastereomer mixtures are available on request to support full impurity-profile coverage.

Allmpus's Capability for This Drug Family

Allmpus Laboratories manufactures and supplies clindamycin phosphate and its related impurities, including EP-designated variants such as Clindamycin Phosphate EP Impurity B and EP Impurity K, as part of a broader clindamycin-family portfolio spanning the hydrochloride, phosphate, and palmitate forms. Because clindamycin phosphate impurities frequently differ from the parent compound by the position of a single phosphate group or a single stereocenter, isolating and confirming these closely related species requires preparative purification techniques capable of resolving subtle positional and stereochemical differences. Each compound is released with a Certificate of Analysis comprising ¹H NMR, ¹³C NMR, mass spectrometry, HPLC purity, IR, and TGA data, supporting customers' method validation, impurity qualification, and regulatory documentation requirements. Allmpus's R&D and manufacturing operations, based in Maharashtra, India, support API manufacturers, generic drug developers, and contract research organizations sourcing clindamycin-related reference standards for QC testing and DMF/ANDA support work.

Frequently Asked Questions

Why do clindamycin phosphate impurities include phosphorylation at different positions (2-, 3-, and 4-phosphate)?

During the phosphorylation reaction, incomplete selectivity can result in the phosphate group attaching to a hydroxyl position other than the intended 2-position, producing regioisomeric impurities such as Clindamycin 3-Phosphate and Clindamycin 4-Phosphate that must be resolved and controlled.

What is Diclindamycin Pyrophosphate (EP Impurity K) and why does it matter?

It is a dimeric impurity formed when two clindamycin phosphate molecules condense through their phosphate groups, and it is monitored as part of the Ph. Eur. related-substance testing for the clindamycin phosphate drug substance.

Is Clindamycin Phosphate EP Impurity L the same as the 7-Epiclindamycin impurity seen in clindamycin hydrochloride?

It is the phosphorylated form of the same 7-position epimer, meaning the underlying stereochemical impurity originates from the clindamycin starting material and carries through into the phosphate ester form.