Ivermectin Impurity Standards

Ivermectin impurity reference standards are used by pharmaceutical quality-control laboratories, contract research organisations, and generic drug manufacturers to identify, quantify, and control Ivermectin-related impurities during analytical method development, method validation, and regulatory filing. As a antiparasitic macrocyclic lactone, Ivermectin requires precise characterisation of its process impurities, degradation products, and related substances to meet European Pharmacopoeia (EP), United States Pharmacopeia (USP), and British Pharmacopoeia (BP) monograph requirements. Allmpus Laboratories manufactures and supplies a comprehensive library of Ivermectin impurity standards, each provided with a Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS). All products are held in-stock for rapid dispatch and are suitable for use in ANDA and DMF regulatory submissions.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

22,23-DIHYDROAVERMECTIN B1A

Chemical Name: 22,23-Dihydroavermectin B1a

CAS No:
94837-49-7

Molecular Formula: C48H75O17P

Molecular Weight: 955.1

CAT No:
ALL-IVE-DYB

Keywords: SMILES string - O[C@@]1([C@]([H])(OC/C1=...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

24-ETHYL IVERMECTIN

Chemical Name: 24-Ethylivermectin B1a

CAS No:
N.A.

Molecular Formula: C49H76O14

Molecular Weight: 889.1

CAT No:
ALL-IVE-EHY

Keywords: SMILES string - C[C@@H]1O[C@](O[C@H]2[C@...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

3-O-DEMETHYL IVERMECTIN B1A

Chemical Name: Spiro[11,15-methano-2H,13H,17H-furo[4,3,...

CAS No:
92137-95-6

Molecular Formula: C47H72O14

Molecular Weight: 861.07

CAT No:
ALL-IVE-DMY

Keywords: SMILES string - O[C@@H]1[C@@H](O)[C@H](C...

Inventory Status:Delivery 3-4 weeks (Custom Synthesis)

COA MSDS

3�-O-DEMETHYL IVERMECTIN

Chemical Name: Spiro[11,15-methano-2H,13H,17H-furo[4,3,...

CAS No:
92137-95-6

Molecular Formula: C47H72O14

Molecular Weight: 861.1

CAT No:
ALL-IVE-DMY

Keywords: SMILES string - O[C@@H]1[C@@H](O)[C@H](C...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

4A-HYDROXY IVERMECTIN

Chemical Name: 4a-Hydroxy Ivermectin

CAS No:
86629-74-5

Molecular Formula: C48H74O15

Molecular Weight: 891.1

CAT No:
ALL-IVE-4AH

Keywords: SMILES string - C[C@H]([C@@]1([H])O[C@]2...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

8A-HYDROXY IVERMECTIN B1A

Chemical Name: 8a-Hydroxy Ivermectin B1a

CAS No:
127468-07-9

Molecular Formula: C48H74O15

Molecular Weight: 891.1

CAT No:
ALL-IVE-HY8

Keywords: SMILES string - [H][C@]([C@@]([H])(C)/C=...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

8A-OXO AVERMECTIN B1A

Chemical Name: Spiro[11,15-methano-2H,13H,17H-furo[4,3,...

CAS No:
102190-68-1

Molecular Formula: C48H70O15

Molecular Weight: 887.1

CAT No:
ALL-IVE-OX8

Keywords: SMILES string - O[C@@]([C@](C=C1C)([H])C...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

IVERMECTIN

Chemical Name: 22,23-Dihydroavermectin B1,

CAS No:
70288-86-7

Molecular Formula: C48H74O14

Molecular Weight: 875.1

CAT No:
ALL-IVE-867

Keywords: SMILES string - O[C@]1([C@](C=C2C)([H])C...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

IVERMECTIN 8A-HYDROPEROXIDE

Chemical Name: 8a-Hydroperoxide ivermectin

CAS No:
2962875-15-4

Molecular Formula: C48H74O16

Molecular Weight: 907.09

CAT No:
ALL-IVE-HYP

Keywords: SMILES string - O[C@H]1[C@H](C)O[C@@H](O...

Inventory Status:3-4 WEEKS

COA MSDS

IVERMECTIN B1A-D2

Chemical Name: Ivermectin B1a-D2

CAS No:
N.A.

Molecular Formula: C48H72D2O14

Molecular Weight: 877.1

CAT No:
ALL-IVE-BAD

Keywords: SMILES string - O[C@]1([C@@](C=C2C)([H])...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

IVERMECTIN B1B

Chemical Name: 5-O-Demethyl-25-de(1-methylpropyl)-25-(1...

CAS No:
70209-81-3

Molecular Formula: C47H72O14

Molecular Weight: 861.07

CAT No:
ALL-IVE-B1B

Keywords: SMILES string - C[C@@H]1O[C@@](C[C@@H]([...

Inventory Status:3-4 WEEKS

COA MSDS

IVERMECTIN B1B-D2

Chemical Name: Ivermectin B1b-D2

CAS No:
N.A.

Molecular Formula: C47H70D2O14

Molecular Weight: 863.1

CAT No:
ALL-IVE-BBD

Keywords: SMILES string - C[C@@H]1O[C@@](C[C@@H]([...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

IVERMECTIN EP IMPURITY A / AVERMECTIN B1A

Chemical Name: 5-O-Demethylavermectin A1a

CAS No:
65195-55-3

Molecular Formula: C48H72O14

Molecular Weight: 873.08

CAT No:
ALL-IVE-EPA

Keywords: SMILES string - O[C@]1([C@](C=C2C)([H])C...

Inventory Status:3-4 WEEKS

COA MSDS

IVERMECTIN EP IMPURITY B / AVERMECTIN B1B

Chemical Name: 5-O-Demethyl-25-de(1-methylpropyl)-25-(1...

CAS No:
65195-56-4

Molecular Formula: C47H70O14

Molecular Weight: 859.05

CAT No:
ALL-IVE-EPB

Keywords: SMILES string - CC([C@H]([C@H](C=C1)C)O[...

Inventory Status:3-4 WEEKS

COA MSDS

IVERMECTIN EP IMPURITY C

Chemical Name: (23S)-5-O-Demethyl-23-hydroxy-22,23-dihy...

CAS No:
65195-57-5

Molecular Formula: C48H74O15

Molecular Weight: 891.09

CAT No:
ALL-IVE-EPC

Keywords: SMILES string - C[C@H]([C@@]([C@H]([C@@H...

Inventory Status:3-4 WEEKS

COA MSDS

IVERMECTIN EP IMPURITY D / 28-OXO IVERMECTIN B1A

Chemical Name: 5-O-Demethyl-28-oxo-22,23-dihydroavermec...

CAS No:
102190-55-6

Molecular Formula: C48H72O15

Molecular Weight: 889.08

CAT No:
ALL-IVE-EPD

Keywords: SMILES string - C[C@H]([C@@]([C@H](CC1)C...

Inventory Status:3-4 WEEKS

COA MSDS

IVERMECTIN EP IMPURITY E

Chemical Name: 5-O,12-Didemethyl-12-ethyl-22,23-dihydro...

CAS No:
N.A.

Molecular Formula: C49H76O14

Molecular Weight: 889.12

CAT No:
ALL-IVE-EPE

Keywords: SMILES string - O[C@]1([C@H](C(O[C@H](C2...

Inventory Status:3-4 WEEKS

COA MSDS

IVERMECTIN EP IMPURITY F

Chemical Name: 5-O,12-Didemethyl-25-de(1-methylpropyl)-...

CAS No:
N.A.

Molecular Formula: C48H74O14

Molecular Weight: 875.09

CAT No:
ALL-IVE-EPF

Keywords: SMILES string - O[C@]1([C@H](C(O[C@H](C2...

Inventory Status:3-4 WEEKS

COA MSDS

IVERMECTIN EP IMPURITY G

Chemical Name: (6R,13S,25R)-5-O-Demethyl-28-deoxy-6,28-...

CAS No:
73162-95-5

Molecular Formula: C34H50O8

Molecular Weight: 586.76

CAT No:
ALL-IVE-EPG

Keywords: SMILES string - C[C@H]([C@@]([C@H](CC1)C...

Inventory Status:3-4 WEEKS

COA MSDS

IVERMECTIN EP IMPURITY H

Chemical Name: 4′-O-De(2,6-Dideoxy-3-O-methyl-α-L-ar...

CAS No:
71837-27-9

Molecular Formula: C41H62O11

Molecular Weight: 730.92

CAT No:
ALL-IVE-EPH

Keywords: SMILES string - O[C@]1([C@](C=C2C)([H])C...

Inventory Status:3-4 WEEKS

COA MSDS

IVERMECTIN EP IMPURITY J

Chemical Name: 2,3-Didehydro-5-O-demethyl-25-de(1-methy...

CAS No:
N.A.

Molecular Formula: C47H72O14

Molecular Weight: 861.07

CAT No:
ALL-IVE-EPJ

Keywords: SMILES string - O[C@]1(C(C(O[C@H](C2)C[C...

Inventory Status:3-4 WEEKS

COA MSDS

IVERMECTIN EP IMPURITY K

Chemical Name: (4R) and (4S)-5-O-Demethyl-3,4,22,23-tet...

CAS No:
74567-01-4

Molecular Formula: C48H76O14

Molecular Weight: 877.11

CAT No:
ALL-IVE-EPK

Keywords: SMILES string - O[C@]1([C@](CC2C)([H])C(...

Inventory Status:3-4 WEEKS

COA MSDS

IVERMECTIN IMPURITY 1

Chemical Name: 5-O-Demethyl-8a-methoxy-22,23-dihydroave...

CAS No:
N.A.

Molecular Formula: C49H76O15

Molecular Weight: 905.1

CAT No:
ALL-IVE-IP1

Keywords: SMILES string - O[C@H]1[C@H](C)O[C@@H](O...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

IVERMECTIN MONOSACCHARIDE

Chemical Name: (1R,4S,5'S,6R,6'R,8R,10E,12S,1...

CAS No:
123997-64-8

Molecular Formula: C41H62O11

Molecular Weight: 730.9

CAT No:
ALL-IVE-MON

Keywords: SMILES string - O=C1[C@](C/23O)([H])C=C(...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

IVERMECTIN-D2

Chemical Name: 22,23-Dihydroavermectin B1-d2

CAS No:
N.A.

Molecular Formula: C48H72D2O14

Molecular Weight: 877.1

CAT No:
ALL-IVE-ID2

Keywords: SMILES string - O[C@]1([C@](C=C2C)([H])C...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

Key Impurity Variants Available

Ivermectin Impurity A — 22,23-dihydroavermectin B1a (major structural isomer)
Ivermectin Impurity B — 22,23-dihydroavermectin B1b (secondary structural isomer)
Ivermectin Related Substance C — Synthetic precursor intermediate
Ivermectin Degradation Product D — Oxidative degradation metabolite
Ivermectin Process Impurity E — Heavy-metal associated process residue

Allmpus Capability Paragraph

Allmpus Laboratories provides certified reference standards for ivermectin and its pharmacopeial impurities, sourced and characterized to meet EP and USP monograph requirements. Our quality assurance protocols include identity confirmation by HPLC, NMR, and mass spectrometry, with purity assessments conducted using validated chromatographic methods. Each standard is supplied with detailed certificates of analysis, traceability documentation, and stability data supporting long-term storage conditions. We maintain collaborative relationships with regulatory bodies and conduct regular inter-laboratory comparisons to ensure our reference materials align with globally recognized pharmacopeial standards. Our ivermectin impurity portfolio supports pharmaceutical manufacturers, contract research organizations, and testing laboratories in developing robust analytical procedures for routine quality monitoring and regulatory submissions.

Frequently Asked Questions

What is the difference between EP and USP ivermectin impurity standards?

A1: While both pharmacopeias establish limits for ivermectin-related substances, USP monographs may specify additional impurities or different acceptance criteria based on regulatory guidance. Reference standards certified to both EP and USP specifications ensure compatibility with multiple regulatory pathways.

How should ivermectin impurity reference standards be stored to maintain stability?

A2: Most ivermectin impurities require storage at 2–8°C in amber glass vials under inert atmosphere to prevent oxidative degradation. Allmpus provides detailed stability protocols with each standard.

Are Allmpus ivermectin impurity standards suitable for USP monograph compliance?

A3: Yes, all standards are characterized using methods aligned with current USP/EP requirements and include full traceability to primary reference standards.