Milbemycin Impurity Standards
Milbemycin Impurity Standards
Milbemycin impurity reference standards are used by pharmaceutical quality-control laboratories, contract research organisations, and generic drug manufacturers to identify, quantify, and control Milbemycin-related impurities during analytical method development, method validation, and regulatory filing. As a antiparasitic macrocyclic lactone, Milbemycin requires precise characterisation of its process impurities, degradation products, and related substances to meet European Pharmacopoeia (EP), United States Pharmacopeia (USP), and British Pharmacopoeia (BP) monograph requirements. Allmpus Laboratories manufactures and supplies a comprehensive library of Milbemycin impurity standards, each provided with a Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS). All products are held in-stock for rapid dispatch and are suitable for use in ANDA and DMF regulatory submissions.
MILBEMYCIN A3 OXIME
Chemical Name: ((2aE,4E,5�S,6R,6�S,8E,11R,13R,15S,1...
CAS No:
114177-14-9
Molecular Formula: C31H43NO7
Molecular Weight: 541.68
CAT No:
ALL-MIL-1
Keywords: CC1=C[C@@H](C(O2)=O)[C@@](/C(CO3)=C/C=C...
Inventory Status:DELIVERY 3-4 WEEKS
MILBEMYCIN A4 OXIME
Chemical Name: ((2aE,4E,5�S,6R,6�S,8E,11R,13R,15S,1...
CAS No:
93074-04-5
Molecular Formula: C32H45NO7
Molecular Weight: 555.7
CAT No:
ALL-MIL-2
Keywords: O=C(O[C@]1([H])C[C@]2(O[C@](C1)([H])C/C=...
Inventory Status:DELIVERY 3-4 WEEKS
MILBEMYCIN EP IMPURITY A
Chemical Name: (6R,25R)-5-O-Demethyl-28-deoxy-6, 28-epo...
CAS No:
51596-11-3
Molecular Formula: C32H46O7
Molecular Weight: 542.7
CAT No:
ALL-MIL-3
Keywords: CC1=C[C@@H](C(O2)=O)[C@@](/C(CO3)=C/C=C/...
Inventory Status:DELIVERY 3-4 WEEKS
MILBEMYCIN EP IMPURITY B
Chemical Name: (2aE,2?R,2a1S,4E,5?S,6R,6?R,8E,11R,15S,1...
CAS No:
51596-10-2
Molecular Formula: C31H44O7
Molecular Weight: 528.68
CAT No:
ALL-MIL-4
Keywords: CC1=C[C@@H](C(O2)=O)[C@@](/C(CO3)=C/C=C/...
Inventory Status:DELIVERY 3-4 WEEKS
MILBEMYCIN EP IMPURITY C
Chemical Name: (2aE,2?R,2a1S,4E,5?S,6R,6?R,8E,11R,15S,1...
CAS No:
77855-81-3
Molecular Formula: C33H48O7
Molecular Weight: 556.73
CAT No:
ALL-MIL-5
Keywords: CC1=C[C@@H](C(O2)=O)[C@@](/C(CO3)=C/C=C/...
Inventory Status:DELIVERY 3-4 WEEKS
MILBEMYCIN EP IMPURITY D
Chemical Name: (2aE,2?R,2a1S,4E,5?S,6R,6?R,8E,11R,15S,1...
CAS No:
NA
Molecular Formula: C32H46O7
Molecular Weight: 542.7
CAT No:
ALL-MIL-6
Keywords: CC1=C[C@@H](C(O2)=O)[C@@](/C(CO3)=C/C=C/...
Inventory Status:DELIVERY 3-4 WEEKS
MILBEMYCIN EP IMPURITY E / MILBEMYCIN A4 KETO ANALOG
Chemical Name: (2aE,2?R,2a1S,4E,5?S,6R,6?R,8E,11R,15S,1...
CAS No:
86691-97-6
Molecular Formula: C32H44O7
Molecular Weight: 540.69
CAT No:
ALL-MIL-7
Keywords: CC1=C[C@@H](C(O2)=O)[C@@](/C(CO3)=C/C=C/...
Inventory Status:DELIVERY 3-4 WEEKS
MILBEMYCIN EP IMPURITY F
Chemical Name: (2aE,2?R,2a1S,4E,5?S,6R,6?R,8E,11R,15S,1...
CAS No:
86691-98-7
Molecular Formula: C31H42O7
Molecular Weight: 526.66
CAT No:
ALL-MIL-8
Keywords: CC1=C[C@@H](C(O2)=O)[C@@](/C(CO3)=C/C=C/...
Inventory Status:DELIVERY 3-4 WEEKS
MILBEMYCIN EP IMPURITY G
Chemical Name: (2aE,2?R,2a1S,4E,5?S,6R,6?R,8E,11R,15S,...
CAS No:
93074-02-3
Molecular Formula: C33H47NO7
Molecular Weight: 569.7
CAT No:
ALL-MIL-12
Keywords: O/N=C1[C@]2([H])[C@]3(O)[C@@](C(O[C@]4([...
Inventory Status:DELIVERY 3-4 WEEKS
MILBEMYCIN EP IMPURITY H
Chemical Name: (2aE,2?R,2a1S,4E,5?S,6R,6?R,8E,11R,15S,1...
CAS No:
N.A.
Molecular Formula: C31H43NO7
Molecular Weight: 541.7
CAT No:
ALL-MIL-10
Keywords: O/N=C1[C@]2([H])[C@]3(O)[C@@](C(O[C@]4([...
Inventory Status:DELIVERY 3-4 WEEKS
MILBEMYCIN EP IMPURITY I
Chemical Name: 2aE,2?R,2a1S,4E,5?S,6R,6?R,8E,11R,15S,17...
CAS No:
N.A.
Molecular Formula: C32H44O8
Molecular Weight: 556.7
CAT No:
ALL-MIL-11
Keywords: O=C1[C@]2(O)[C@]3(O)[C@@](C(O[C@]4([H])C...
Inventory Status:DELIVERY 3-4 WEEKS
MILBEMYCIN OXIME
Chemical Name: Mixture of (2aE,2?R,2a1S,4E,5?S,6R,6?R,8...
CAS No:
129496-10-2
Molecular Formula: C31H43N07 ;C32H45NO7
Molecular Weight: 541.68 ;555.70
CAT No:
ALL-MIL-9
Keywords: CC1=C[C@@H](C(O2)=O)[C@@](/C(CO3)=C/C=C/...
Inventory Status:DELIVERY 3-4 WEEKS
Key Impurity Variants Available
- Milbemycin EP Impurity A (Milbemycin A4) — CAS 51596-11-3, a principal related macrolide homolog used in EP related-substances testing
- Milbemycin EP Impurity B (Milbemycin A3) — CAS 51596-10-2, the companion homolog required for A3/A4 ratio confirmation
- Milbemycin EP Impurity C (Milbemycin D) — CAS 77855-81-3, a related structural analog listed in the EP monograph
- Milbemycin EP Impurity E (Milbemycin A4 Keto Analog) — CAS 86691-97-6, an oxidation-related degradation product
- Milbemycin EP Impurity F (Milbemycin A3 Keto Analog) — CAS 86691-98-7, the corresponding keto analog of the A3 homolog
Allmpus Capability for This Drug Family
Milbemycin's impurity profile spans a wide range of closely related macrolide homologs, oxime derivatives, and oxidation products, which places substantial demands on isolation and analytical differentiation given the small structural distinctions between related substances. Allmpus Laboratories maintains a dedicated Milbemycin impurity portfolio, including Milbemycin A3 and A4 oximes and EP Impurities A through I, each supplied with a Certificate of Analysis and structural characterization data. This portfolio is developed and manufactured within R&D and manufacturing facilities accredited by USFDA, EU GMP, EDQM, KFDA, and COFEPRIS, supporting method development, forced-degradation studies, and regulatory documentation for milbemycin-containing formulations. Where a specific milbemycin-related substance is required outside the current catalogue, our synthetic chemistry team can undertake custom synthesis or isolation on request.
Frequently Asked Questions
Which Milbemycin EP impurities does Allmpus currently supply?
Allmpus's current portfolio includes Milbemycin A3 and A4 oximes and Milbemycin EP Impurities A through I, covering the principal homologs, keto analogs, and oxime-related substances listed under the EP monograph.
What documentation is provided with these standards?
Each Milbemycin impurity standard is supplied with a Certificate of Analysis and structural characterization data, suitable for use in method validation and regulatory submissions.
What is the typical lead time for Milbemycin impurity standards?
Current inventory listings show a delivery window of 3–4 weeks; contact Allmpus directly to confirm lead times for specific catalogue numbers or bulk quantities.