Vancomycin Impurity Standards

Vancomycin impurity reference standards are used by pharmaceutical quality-control laboratories, contract research organisations, and generic drug manufacturers to identify, quantify, and control Vancomycin-related impurities during analytical method development, method validation, and regulatory filing. As a glycopeptide antibiotic, Vancomycin requires precise characterisation of its process impurities, degradation products, and related substances to meet European Pharmacopoeia (EP), United States Pharmacopeia (USP), and British Pharmacopoeia (BP) monograph requirements. Allmpus Laboratories manufactures and supplies a comprehensive library of Vancomycin impurity standards, each provided with a Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS). All products are held in-stock for rapid dispatch and are suitable for use in ANDA and DMF regulatory submissions.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VANCOMYCIN DIDECHLORO IMPURITY

Chemical Name: Didechloro Vancomycin B

CAS No:
98510-30-6

Molecular Formula: C66H77N9O24

Molecular Weight: 1379.5

CAT No:
ALL-VN08092

Keywords: SMILES string -N[C@@](C[C@@H]1O[C@H]([C@...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN EP IMPURITY J

Chemical Name: VANCOMYCIN EP IMPURITY J

CAS No:
2416251-24-4

Molecular Formula: C66H75Cl2N9O24

Molecular Weight: 1449.3

CAT No:
ALL-VN08094

Keywords: SMILES string - O[C@H]([C@H]1O[C@@H]2O[...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

(RS1) [D-VAL] VANCOMYCIN B

Chemical Name: (3S,6R,7R,22R,23S,26S,30aSa,36R,38aR)-3-...

CAS No:
N.A

Molecular Formula: C65H73Cl2N9O24

Molecular Weight: 1435.2

CAT No:
ALL-VN08017

Keywords: SMILES string - OC1=CC=C([C@](NC([C@]2(...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

22-DEOXYVANCOMYCIN B

Chemical Name: 22-DEOXYVANCOMYCIN B

CAS No:
1378999-72-4

Molecular Formula: C66H75Cl2N9O23

Molecular Weight: 1433.3

CAT No:
ALL-VN08018

Keywords: SMILES string - OC1=CC(O)=C(C2=CC([C@@]...

Inventory Status:DELIVERY 3-4 WEEKS

COA MSDS

7-DEHYDROXYVANCOMYCIN B

Chemical Name: 7-DEHYDROXYVANCOMYCIN B

CAS No:
1141925-31-6

Molecular Formula: C66H75Cl2N9O23

Molecular Weight: 1433.3

CAT No:
ALL-VN08019

Keywords: SMILES string - O[C@H]([C@H]1O[C@@H]2O[...

Inventory Status:Delivery 3-4 weeks (Custom Synthesis)

COA MSDS

DEMETHYLVANCOMYCIN B

Chemical Name: DEMETHYLVANCOMYCIN B

CAS No:
N.A

Molecular Formula: C65H73Cl2N9O24

Molecular Weight: 1435.2

CAT No:
ALL-VN08020

Keywords: SMILES string - OC1=CC([C@@](C(O)=O)([H...

Inventory Status:Delivery 3-4 weeks (Custom Synthesis)

COA MSDS

ISOMER OF DEMETHYLVANCOMYCIN B

Chemical Name: ISOMER OF DEMETHYLVANCOMYCIN B

CAS No:
N.A

Molecular Formula: C65H73Cl2N9O24

Molecular Weight: 1435.2

CAT No:
ALL-VN08090

Keywords: SMILES string - OC1=CC([C@@](C(O)=O)([H...

Inventory Status:Delivery 3-4 weeks (Custom Synthesis)

COA MSDS

VANCOMYCIN DESCHLORO IMPURITY

Chemical Name: VANCOMYCIN DESCHLORO IMPURITY

CAS No:
N.A

Molecular Formula: C66H75ClN8O25

Molecular Weight: 1415.8

CAT No:
ALL-VN08025

Keywords: SMILES string - OC1=CC([C@@](C(O)=O)(NC...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN EP IMPURITY A

Chemical Name: N2.1-demethylvancomycin B (as per EP)

CAS No:
91700-98-0

Molecular Formula: C65H73Cl2N9O24

Molecular Weight: 1435.2

CAT No:
ALL-VN08093

Keywords: SMILES string - OC1=CC([C@@]([H])(C(O)=...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN EP IMPURITY B

Chemical Name: (1.2M)-[L-β-Asp3]vancomycin B (3.2-syn-...

CAS No:
N.A

Molecular Formula: C66H74Cl2N8O25

Molecular Weight: 1450.2

CAT No:
ALL-VN08028

Keywords: SMILES string - OC1=CC([C@@]([H])(C(O)=...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN EP IMPURITY B2

Chemical Name: VANCOMYCIN EP IMPURITY B2

CAS No:
N.A

Molecular Formula: C66H74Cl2N8O25

Molecular Weight: 1450.2

CAT No:
ALL-VN08095

Keywords: SMILES string - OC1=CC=C([C@](NC([C@]2(...

Inventory Status:Delivery 3-4 weeks (Custom Synthesis)

COA MSDS

VANCOMYCIN EP IMPURITY C

Chemical Name: O4.4-de-[2-O-(3-amino-2,3,6-trideoxy-3-C...

CAS No:
82198-76-3

Molecular Formula: C53H52Cl2N8O17

Molecular Weight: 1143.9

CAT No:
ALL-VN08017

Keywords: SMILES string - OC1=CC(O)=C(C2=CC([C@](...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN EP IMPURITY D

Chemical Name: O4.4-de-[2-O-(3-amino-2,3,6-trideoxy-3-C...

CAS No:
101485-50-1

Molecular Formula: C59H62Cl2N8O22

Molecular Weight: 1306.1

CAT No:
ALL-VN08022

Keywords: SMILES string - OC1=CC(O)=C(C2=CC([C@](...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN EP IMPURITY E

Chemical Name: [L-β-Asp3]vancomycin B (CDP-1 minor) (a...

CAS No:
N.A

Molecular Formula: C66H74Cl2N8O25

Molecular Weight: 1450.2

CAT No:
ALL-VN08050

Keywords: SMILES string - ClC1=CC([C@@]([H])(O)[C...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN EP IMPURITY F

Chemical Name: [L-α-Gln3]vancomycin B (as per EP)

CAS No:
2415254-43-0

Molecular Formula: C67H77Cl2N9O24

Molecular Weight: 1463.3

CAT No:
ALL-VN08094

Keywords: SMILES string - ClC1=CC([C@@]([H])(O)[C...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN EP IMPURITY G

Chemical Name: 4.3,Nα,4-anhydro-[L-α-Asp3]vancomycin ...

CAS No:
N.A

Molecular Formula: C66H72Cl2N8O24

Molecular Weight: 1432.2

CAT No:
ALL-VN08015

Keywords: SMILES string - ClC1=CC([C@@]([H])(O)[C...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN EP IMPURITY H

Chemical Name: 3.6-Dechlorovancomycin B (as per EP)

CAS No:
357396-41-9

Molecular Formula: C66H76ClN9O24

Molecular Weight: 1414.8

CAT No:
ALL-VN08016

Keywords: SMILES string - ClC1=CC([C@@]([H])(O)[C...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN EP IMPURITY I

Chemical Name: (1.2M)-vancomycin (as per EP)

CAS No:
N.A

Molecular Formula: C66H75Cl2N9O24

Molecular Weight: 1449.3

CAT No:
ALL-VN08049

Keywords: SMILES string - O[C@H]([C@H]1O[C@@H]2O[...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN EP IMPURITY K

Chemical Name: [N,N-dimethyl-D-Leu1]vancomycin B (as pe...

CAS No:
99759-13-4

Molecular Formula: C67H77Cl2N9O24

Molecular Weight: 1463.3

CAT No:
ALL-VN08063

Keywords: SMILES string - O[C@H]([C@H]1O[C@@H]2O[...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN EP IMPURITY L

Chemical Name: [L-α-Asp3]vancomycin B) (as per EP)

CAS No:
N.A

Molecular Formula: C66H74Cl2N8O25

Molecular Weight: 1450.2

CAT No:
ALL-VN08014

Keywords: SMILES string - O[C@H]([C@H]1O[C@@H]2O[...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN HYDROCHLORIDE

Chemical Name: Monohydrochloride of (3S,6R,7R,8M,18M,22...

CAS No:
1404-93-9

Molecular Formula: C66H75Cl2N9O24 : HCl

Molecular Weight: 1449.3 : 36.5

CAT No:
ALL-VN08049

Keywords: SMILES string - O[C@@H]1[C@@H](O[C@@](O...

Inventory Status:Delivery 3-4 weeks (Custom Synthesis)

COA MSDS

VANCOMYCIN METHYL ESTER

Chemical Name: VANCOMYCIN METHYL ESTER

CAS No:
250273-66-6

Molecular Formula: C67H77Cl2N9O24

Molecular Weight: 1463.3

CAT No:
ALL-VN08091

Keywords: SMILES string - OC1=CC(O)=C(C2=CC([C@@]...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

VANCOMYCIN MIXTURE OF EP IMPURITY B AND EP IMPURITY E

Chemical Name: Vancomycin Mixture of CDP-1 major and CD...

CAS No:
N.A

Molecular Formula: C66H74Cl2N8O25

Molecular Weight: 1450.2

CAT No:
ALL-VN08014

Keywords: SMILES string - OC[C@@H]1[C@H](O)[C@H](...

Inventory Status:Delivery IMMEDIATE

COA MSDS

VANCOMYCIN QUINONE IMPURITY

Chemical Name: Vancomycin Quinone Impurity

CAS No:
N.A.

Molecular Formula: C66H73Cl2N9O24

Molecular Weight: 1447.2

CAT No:
ALL-VN08096

Keywords: SMILES string - C[C@H](O[C@](C[C@@]1(N)C...

Inventory Status:DELIVERY IMMEDIATE

COA MSDS

Key Vancomycin Impurity Variants

Vancomycin EP Impurity A (N — Desmethyl Vancomycin B, CAS 91700-98-0)-a demethylated analogue formed during fermentation, listed as a specified impurity in the Ph. Eur. monograph
Vancomycin EP Impurity B / CDP — 1 major ([L-β-Asp3]vancomycin B, CAS 55598-85-1 for the CDP-1 mixture)-the major isomer of Crystalline Degradation Product-1, formed via deamidation of an asparagine residue
Vancomycin EP Impurity E / CDP — 1 minor ([L-β-Asp3]vancomycin B, minor isomer)-the minor CDP-1 isomer, typically supplied alongside Impurity B as a mixture reflecting real-world degradation profiles
Vancomycin EP Impurity G (4.3,Nα,4 — anhydro-[L-α-Asp3]vancomycin B)-an anhydro degradation product listed in the Ph. Eur. monograph
Vancomycin EP Impurity L ([L — α-Asp3]Vancomycin B, CAS 79517-31-0)-a related deamidation isomer used to confirm chromatographic resolution from Impurity B and E
Additional EP — lettered impurities (including Impurity D, desvancosaminylvancomycin B, and Impurity J, 26-epi-Vancomycin B) are available on request for full impurity-profile coverage.

Allmpus's Capability for This Drug Family

Allmpus Laboratories manufactures and supplies vancomycin-related impurities, including EP-lettered degradation products such as Vancomycin EP Impurity G, released with full Certificates of Analysis. Given that many vancomycin impurities differ from the parent molecule by subtle changes such as deamidation, ring contraction, or loss of a single chlorine or methyl group, isolating and confirming these species requires preparative purification techniques capable of resolving closely related glycopeptide structures. Each compound is released with a Certificate of Analysis comprising ¹H NMR, ¹³C NMR, mass spectrometry, HPLC purity, IR, and TGA data, supporting customers' method validation, impurity qualification, and regulatory documentation requirements. Allmpus's R&D and manufacturing operations, based in Maharashtra, India, support API manufacturers, generic injectable developers, and contract research organizations sourcing vancomycin-related reference standards for QC testing and DMF/ANDA support work.

Frequently Asked Questions

What is CDP-1 and why does it matter for vancomycin quality control?

CDP-1 (Crystalline Degradation Product-1) forms through deamidation of an asparagine residue in vancomycin B and exists as major (Impurity B) and minor (Impurity E) isomers; it can accumulate during storage or in patients with reduced renal clearance and is known to interfere with certain vancomycin immunoassays.

Why are Vancomycin EP Impurity B and E often supplied together?

Because CDP-1 naturally forms as a mixture of the two isomers during degradation, supplying them together better reflects real degradation profiles encountered in stability testing and helps confirm that analytical methods can resolve both species.

What documentation is provided with vancomycin impurity standards?

Each standard is supplied with a Certificate of Analysis including spectroscopic (NMR, MS, IR) and chromatographic (HPLC) data, along with thermal analysis (TGA) where applicable, to support characterization and regulatory documentation requirements.