Medical Chemistry

The Allmpus offers the following MedChem services:

• Design and synthesis of novel chemical entities for hit finding strategies, hit-to-lead identification and lead optimization.
• Biological profiling of the designed compounds (In collaboration with our in-vitro and in-vivo biology & DMPK groups).
• IPR evaluation and generation of the scaffolds.
• Designing novel chemical entities (in collaboration with in Silico Molecular Modelling Group).
• Structure based drug design (in collaboration with structural biology group).

The ALLMPUS team responsible for implementing medicinal chemistry services comprises knowledgeable and seasoned medicinal chemists who are not only well-trained in one discipline but have experience in bringing all the elements together into one focused drug discovery program.

Working together with our Structural Biology and Computational Chemistry groups, the MedChem team is well versed in interpreting biological data to optimize compounds to meet all the requirements of a viable clinical candidate.

• Has a track record of delivering clinical candidates starting from, for example, in-silico screening hits, in a short time. Comprises of 80-150 research chemists.
• Has expertise in every step of the drug discovery process, starting from early-stage target identification, through hit identification, hit to lead identification and then lead optimization, leading to the identification of pre-clinical candidates.

The medicinal chemistry team has a performance history of solving the various problems often encountered during the optimization discovery and optimization process, such as potency, selectivity, specificity, off-target activity, physicochemical properties, DMPK related issues, safety-related issues and such. They have accumulated expertise in various therapeutic areas over the years, including, but not limited to, oncology, metabolic disorders, inflammation and CNS.

Chemists at our Contract Research, Development and Manufacturing Organization have worked on integrated drug discovery programs yielding a pre-clinical candidates, out of which few compounds have advanced into the later phase of developments & clinics. The group also has strong organic synthesis capabilities and can offer pharmaceutical chemistry services independently or as part of an integrated program.

Need to make tree diagrams

Target Validation & Desing of NCE’S ------ Hit Identification & Lead Optimization ------- Candidate Selection & Process Development ------GMP Manufacturing & IND Filing

Allmpus focus on discovery program and identified Hit on target EGFR and few other, currently our team of scientist working on Hit to Lead and Lead optimization program for Allmpus.