API Impurities Standard
ABEMACICLIB NITROSO IMPURITY 5
Category: Abemaciclib Impurity
- Chemical Name: N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-2-methyl-1-nitroso-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
- Molecular Formula: C24H25F2N9O
- Molecular Weight: 493.5
- CAS Number: N.A.
- Batch Number: ALL-A07556
- Solubility: USP Diluent / EP Diluent (MEOH)
- Storage:
- Purity by HPLC: 98.00%
- Melting Point:
- Appearance: OFF WHITE SOLID
- Inventory Status: DELIVERY 3-4 WEEKS
- Smiles CCN(CC1)CCN1CC2=CC=C(NC3=NC(C4=CC(F)=C(N=C(C)N5N=O)C5=C4)=C(F)C=N3)N=C2
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Description
Documents 1. COA, HNMR, MASS, HPLC, IR, TGA analysis data will be offered along with products. 2. Quotation validity # 4 weeks 3. GST applicable # 18% 4. Lead time # the custom synthesis products are quoted with an optimistic time-line and actual time-line may vary based on raw material availability, synthetic and purification challenges. 5. The COA attached are for reference only. We will include details in the COA as per your requirement in the release data during dispatch. 6. Kindly mentioned in case of procurement if these products are intended for regulatory deficiency by returned e-mail.
Related Products
Abemaciclib
Chemical Name: N-(5-((4-Ethylpiperazin-1-yl)methyl)pyri...
CAS No: 1231929-97-7
Molecular Formula: C27H32F2N8
Molecular Weight: 506.6
CAT No: ALL-A07492
Keywords: Abemaciclib
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Abemaciclib Impurity 12
Chemical Name: (6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-...
CAS No: 1648707-16-7
Molecular Formula: C21H20F2N6O
Molecular Weight: 410.4
CAT No: ALL-A07493
Keywords: Abemaciclib Impurity 12
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Abemaciclib Impurity 13
Chemical Name: N-(5-((4-Ethylpiperazin-1-yl)methyl)pyri...
CAS No: N.A
Molecular Formula: C27H32F2N8
Molecular Weight: 506.6
CAT No: ALL-A07494
Keywords: Abemaciclib Impurity 13
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 20
Chemical Name: 6-Bromo-4-fluoro-2-methyl-1-propyl-1H-be...
CAS No: 1844847-62-6
Molecular Formula: C11H12BrFN2
Molecular Weight: 271.1
CAT No: ALL-A07495
Keywords: Abemaciclib Impurity 20
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 22
Chemical Name: N'-(4-Bromo-2,6-difluorophenyl)-N-i...
CAS No: 1231930-29-2
Molecular Formula: C11H13BrF2N2
Molecular Weight: 291.1
CAT No: ALL-A07496
Keywords: Abemaciclib Impurity 22
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 24
Chemical Name: Tert-butyl 4-((6-aminopyridin-3-yl)meth...
CAS No: 1178566-52-3
Molecular Formula: C15H24N4O2
Molecular Weight: 292.4
CAT No: ALL-A07497
Keywords: Abemaciclib Impurity 24
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 25
Chemical Name: 2-Chloro-N-(5-((4-ethylpiperazin-1-yl)me...
CAS No: N.A
Molecular Formula: C16H20ClFN6
Molecular Weight: 350.8
CAT No: ALL-A07498
Keywords: Abemaciclib Impurity 25
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 26
Chemical Name: 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H...
CAS No: 1231930-33-8
Molecular Formula: C11H12BrFN2
Molecular Weight: 271.1
CAT No: ALL-A07499
Keywords: Abemaciclib Impurity 26
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 3
Chemical Name: 1-Ethyl-4-(pyridin-3-ylmethyl)piperazine
CAS No: 414881-11-1
Molecular Formula: C12H19N3
Molecular Weight: 205.3
CAT No: ALL-A07500
Keywords: Abemaciclib Impurity 3
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 6
Chemical Name: 4-Fluoro-1-isopropyl-2-methyl-1H-benzo[d...
CAS No: 1528469-78-4
Molecular Formula: C11H13FN2
Molecular Weight: 192.2
CAT No: ALL-A07501
Keywords: Abemaciclib Impurity 6
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 7
Chemical Name: 6-Bromo-1-isopropyl-2-methyl-1H-benzo[d]...
CAS No: 1038408-36-4
Molecular Formula: C11H13BrN2
Molecular Weight: 253.1
CAT No: ALL-A07502
Keywords: Abemaciclib Impurity 7
Inventory Status:3-4 WEEKS
Abemaciclib Metabolites M2
Chemical Name: 5-Fluoro-4-(4-fluoro-1-isopropyl-2-methy...
CAS No: 1231930-57-6
Molecular Formula: C25H28F2N8
Molecular Weight: 478.6
CAT No: ALL-A07503
Keywords: Abemaciclib Metabolites M2
Inventory Status:3-4 WEEKS
TWO METHANOL ABEMACICLIB
Chemical Name: (6-(2-((5-((4-Ethylpiperazin-1-yl)methyl...
CAS No: 2138499-06-4
Molecular Formula: C27H32F2N8O
Molecular Weight: 522.6
CAT No: ALL-A07504
Keywords: CC(N1C2=CC(C3=NC(NC(N=C4)=CC=C4CN(CC5)CC...
Inventory Status:3-4 WEEKS
Abemaciclib Desfluoro Pyrimidine Imidazole Impurity
Chemical Name: N-(5-((4-ethylpiperazin-1-yl)methyl)pyr...
CAS No: N.A
Molecular Formula: C27H33FN8
Molecular Weight: 488.6
CAT No: ALL-A07505
Keywords: Abemaciclib Desfluoro Pyrimidine Imidazo...
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 1
Chemical Name: 5-((4-Ethylpiperazin-1-yl)methyl)pyridi...
CAS No: 1180132-17-5
Molecular Formula: C12H20N4
Molecular Weight: 220.3
CAT No: ALL-A07506
Keywords: Abemaciclib Impurity 1
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 10
Chemical Name: 4-Fluoro-1-isopropyl-2-methyl-6-(4,4,5,5...
CAS No: 1231930-37-2
Molecular Formula: C17H24BFN2O2
Molecular Weight: 318.2
CAT No: ALL-A07507
Keywords: Abemaciclib Impurity 10
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 11
Chemical Name: 6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-m...
CAS No: 1627082-92-1
Molecular Formula: C21H18F2N6O
Molecular Weight: 408.4
CAT No: ALL-A07508
Keywords: Abemaciclib Impurity 11
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 14
Chemical Name: N-(5-((4-Ethylpiperazin-1-yl)methyl)pyri...
CAS No: N.A
Molecular Formula: C42H44F4N12
Molecular Weight: 792.9
CAT No: ALL-A07509
Keywords: Abemaciclib Impurity 14
Inventory Status:3-4 WEEKS
ABEMACICLIB IMPURITY 15
Chemical Name: N,N'-((piperazine-1,4-diylbis(methy...
CAS No: N.A
Molecular Formula: C46H46F4N14
Molecular Weight: 871.0
CAT No: ALL-A07510
Keywords: FC1=C2C(N(C(C)C)C(C)=N2)=CC(C3=C(F)C=NC(...
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 17
Chemical Name: 4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-i...
CAS No: N.A
Molecular Formula: C28H33F2N7O
Molecular Weight: 521.6
CAT No: ALL-A07512
Keywords: Abemaciclib Impurity 17
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 16
Chemical Name: 1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-i...
CAS No: NA
Molecular Formula: C28H33F2N7O2
Molecular Weight: 537.6
CAT No: ALL-A07511
Keywords: Abemaciclib Impurity 16
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 18
Chemical Name: 1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-i...
CAS No: N.A
Molecular Formula: C28H33F2N7O
Molecular Weight: 521.6
CAT No: ALL-A07513
Keywords: Abemaciclib Impurity 18
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 19
Chemical Name: 1-((6-Bromopyridin-3-yl)methyl)-4-ethylp...
CAS No: 1231930-25-8
Molecular Formula: C12H18BrN3
Molecular Weight: 284.2
CAT No: ALL-A07514
Keywords: Abemaciclib Impurity 19
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 2
Chemical Name: 6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fl...
CAS No: 1231930-42-9
Molecular Formula: C15H13ClF2N4
Molecular Weight: 322.7
CAT No: ALL-A07515
Keywords: Abemaciclib Impurity 2
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 21
Chemical Name: 6-Bromo-1-ethyl-4-fluoro-2-methyl-1H-ben...
CAS No: 2189739-28-2
Molecular Formula: C10H10BrFN2
Molecular Weight: 257.1
CAT No: ALL-A07516
Keywords: Abemaciclib Impurity 21
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 23
Chemical Name: 6-(4-Chloro-5-fluoropyrimidin-2-yl)-4-fl...
CAS No: N.A
Molecular Formula: C15H13ClF2N4
Molecular Weight: 322.7
CAT No: ALL-A07517
Keywords: Abemaciclib Impurity 23
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 27
Chemical Name: (4-Fluoro-1-isopropyl-2-methyl-1H-benzo...
CAS No: 2346512-66-9
Molecular Formula: C11H14BFN2O2
Molecular Weight: 236.1
CAT No: ALL-A07518
Keywords: Abemaciclib Impurity 27
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 5
Chemical Name: 4-Fluoro-6-(5-fluoropyrimidin-4-yl)-1-is...
CAS No: N.A
Molecular Formula: C15H14F2N4
Molecular Weight: 288.3
CAT No: ALL-A07519
Keywords: Abemaciclib Impurity 5
Inventory Status:3-4 WEEKS
Abemaciclib Nitroso Impurity 4
Chemical Name: 5-((4-Ethylpiperazin-1-yl)methyl)-2-((5-...
CAS No: N.A
Molecular Formula: C28H33F2N7O
Molecular Weight: 521.6
CAT No: ALL-A07520
Keywords: Abemaciclib Nitroso Impurity 4
Inventory Status:3-4 WEEKS
Abemaciclib N-Oxide Impurity 1
Chemical Name: 4-Ethyl-1-((6-((5-fluoro-4-(4-fluoro-1-i...
CAS No: N.A
Molecular Formula: C27H32F2N8O
Molecular Weight: 522.6
CAT No: ALL-A07521
Keywords: Abemaciclib N-Oxide Impurity 1
Inventory Status:3-4 WEEKS
Abemaciclib N-Oxide Impurity 2
Chemical Name: 1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-i...
CAS No: N.A
Molecular Formula: C27H32F2N8O
Molecular Weight: 522.6
CAT No: ALL-A07522
Keywords: Abemaciclib N-Oxide Impurity 2
Inventory Status:3-4 WEEKS
ABEMACICLIB N-OXIDE IMPURITY 3
Chemical Name: 5-((4-Ethylpiperazin-1-yl)methyl)-2-((5-...
CAS No: N.A.
Molecular Formula: C27H32F2N8O
Molecular Weight: 522.6
CAT No: ALL-A07523
Keywords: CC1=NC2=C(F)C=C(C3=NC(NC4=CC=C(CN5CCN(CC...
Inventory Status:3-4 WEEKS
Abemaciclib Impurity 28
Chemical Name: N-(5-((4-Ethylpiperazin-1-yl)methyl)pyri...
CAS No: N.A
Molecular Formula: C27H33FN8
Molecular Weight: 488.6
CAT No: ALL-A07524
Keywords: Abemaciclib Impurity 28
Inventory Status:3-4 WEEKS
Abemaciclib Metabolite M18
Chemical Name: (4-Fluoro-6-(5-fluoro-2-((5-(piperazin-1...
CAS No: 2704316-81-2
Molecular Formula: C25H28F2N8O
Molecular Weight: 494.6
CAT No: ALL-A07525
Keywords: Abemaciclib Metabolite M18
Inventory Status:3-4 WEEKS
Abemaciclib Nitroso Impurity 3
Chemical Name: 1-((6-Bromopyridin-3-yl)methyl)-4-nitros...
CAS No: N.A
Molecular Formula: C10H13BrN4O
Molecular Weight: 285.1
CAT No: ALL-A07530
Keywords: Abemaciclib Nitroso Impurity 3
Inventory Status:3-4 WEEKS
Abemaciclib Nitroso Impurity 2
Chemical Name: 5-((4-Nitrosopiperazin-1-yl)methyl)pyrid...
CAS No: N.A
Molecular Formula: C10H15N5O
Molecular Weight: 221.3
CAT No: ALL-A07531
Keywords: Abemaciclib Nitroso Impurity 2
Inventory Status:3-4 WEEKS
Abemaciclib Nitroso Metabolites M2
Chemical Name: 5-Fluoro-4-(4-fluoro-1-isopropyl-2-methy...
CAS No: N.A
Molecular Formula: C25H27F2N9O
Molecular Weight: 507.5
CAT No: ALL-A07532
Keywords: Abemaciclib Nitroso Metabolites M2
Inventory Status:3-4 WEEKS
Abemaciclib Nitroso Impurity 1
Chemical Name: N-(5-((4-Ethylpiperazin-1-yl)methyl)pyri...
CAS No: N.A
Molecular Formula: C27H31F2N9O
Molecular Weight: 535.6
CAT No: ALL-A07533
Keywords: Abemaciclib Nitroso Impurity 1
Inventory Status:3-4 WEEKS
ABEMACICLIB IMPURITY 40
Chemical Name: 5-Fluoro-4-(4-fluoro-1-isopropyl-2-methy...
CAS No: 2055637-56-2
Molecular Formula: C15H15F2N5
Molecular Weight: 303.3
CAT No: ALL-A07534
Keywords: NC1=NC=C(F)C(C2=CC(F)=C3C(N(C(C)C)C(C)=N...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB N-OXIDE IMPURITY 4
Chemical Name: 1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-i...
CAS No: N.A.
Molecular Formula: C27H32F2N8O2
Molecular Weight: 538.6
CAT No: ALL-A07535
Keywords: CC1=NC2=C(F)C=C(C3=NC(NC4=CC=C(C[N+]5([O...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB ALCOHOL DIMER IMPURITY
Chemical Name: 5-Fluoro-4-(4-fluoro-1-isopropyl-2-methy...
CAS No: N.A.
Molecular Formula: C37H33F4N9O
Molecular Weight: 695.7
CAT No: ALL-A07536
Keywords: CC1=NC2=C(F)C=C(C3=NC=CC(OCC4=CN=C(NC5=N...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB DESETHYL DIMER IMPURITY
Chemical Name: 5-Fluoro-4-(4-fluoro-1-isopropyl-2-methy...
CAS No: N.A.
Molecular Formula: C40H40F4N12
Molecular Weight: 764.8
CAT No: ALL-A07537
Keywords: CC1=NC2=C(F)C=C(C3=NC(N4CCN(CC5=CN=C(NC6...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 29
Chemical Name: 6-(2-Chloro-5-fluoropyrimidin-4-yl)-1-i...
CAS No: 1873303-32-2
Molecular Formula: C15H14ClFN4
Molecular Weight: 304.8
CAT No: ALL-A07538
Keywords: CC(N1C2=CC(C3=NC(Cl)=NC=C3F)=CC=C2N=C1C)...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 30
Chemical Name: 6-(2-Chloropyrimidin-4-yl)-4-fluoro-1-is...
CAS No: 1231930-47-4
Molecular Formula: C15H14ClFN4
Molecular Weight: 304.8
CAT No: ALL-A07539
Keywords: CC(N1C2=CC(C3=NC(Cl)=NC=C3)=CC(F)=C2N=C1...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 31
Chemical Name: (4-Ethylpiperazin-1-yl)(6-((5-fluoro-4-(...
CAS No: 1873299-08-1
Molecular Formula: C27H30F2N8O
Molecular Weight: 520.6
CAT No: ALL-A07540
Keywords: CC(N1C2=CC(C3=NC(NC(N=C4)=CC=C4C(N(CC5)C...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 32
Chemical Name: 6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-m...
CAS No: N.A.
Molecular Formula: C20H18F2N6O
Molecular Weight: 396.4
CAT No: ALL-A07541
Keywords: CC(C)N1C2=CC(C3=NC(NC4=CC=C(C=N4)O)=NC=C...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 33
Chemical Name: 6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-...
CAS No: N.A.
Molecular Formula: C21H18F2N6O2
Molecular Weight: 424.4
CAT No: ALL-A07542
Keywords: CC(C)N1C2=CC(C3=NC(NC4=CC=C(C=N4)C(O)=O)...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 34
Chemical Name: 4-Bromo-2,6-difluoroaniline
CAS No: 67567-26-4
Molecular Formula: C6H4BrF2N
Molecular Weight: 208.0
CAT No: ALL-A07543
Keywords: NC(C(F)=CC(Br)=C1)=C1F
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 35
Chemical Name: 5-((4-Methylpiperazin-1-yl)methyl)pyridi...
CAS No: 1197333-44-0
Molecular Formula: C11H18N4
Molecular Weight: 206.3
CAT No: ALL-A07544
Keywords: NC1=NC=C(C=C1)CN(CC2)CCN2C
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 36
Chemical Name: 6,6'-(5-fluoropyrimidine-2,4-diyl)b...
CAS No: N.A.
Molecular Formula: C26H25F3N6
Molecular Weight: 478.5
CAT No: ALL-A07545
Keywords: FC1=CN=C(C2=CC(F)=C3C(N(C(C)C)C(C)=N3)=C...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 38
Chemical Name: 6,6'-(5,5'-difluoro-[2,2'...
CAS No: 2134976-95-5
Molecular Formula: C30H26F4N8
Molecular Weight: 574.6
CAT No: ALL-A07546
Keywords: FC1=CN=C(C2=NC=C(F)C(C3=CC(F)=C4C(N(C(C)...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 39
Chemical Name: 5-(Piperazin-1-ylmethyl)pyridin-2-amine
CAS No: 1178566-47-6
Molecular Formula: C10H16N4
Molecular Weight: 192.3
CAT No: ALL-A07547
Keywords: NC1=NC=C(C=C1)CN2CCNCC2
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 41
Chemical Name: 1,4-bis((6-chloropyridin-3-yl)methyl)pip...
CAS No: 230617-68-2
Molecular Formula: C16H18Cl2N4
Molecular Weight: 337.2
CAT No: ALL-A07548
Keywords: ClC1=CC=C(CN2CCN(CC3=CC=C(Cl)N=C3)CC2)C=...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 42
Chemical Name: Bis(5-fluoro-4-(4-fluoro-1-isopropyl-2-m...
CAS No: N.A.
Molecular Formula: C32H29F4N7
Molecular Weight: 587.6
CAT No: ALL-A07549
Keywords: CC1=NC2=C(F)C=C(C3=CC(NC4=NC=C(F)C(C5=CC...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 43
Chemical Name: 7,7'-Difluoro-3,3'-diisopropyl...
CAS No: 3062616-90-1
Molecular Formula: C22H24F2N4
Molecular Weight: 382.5
CAT No: ALL-A07550
Keywords: CC1=NC2=C(F)C=C(C3=CC(F)=C4N=C(C)N(C(C)C...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 44
Chemical Name: 6-Chloro-5-fluoropyrimidin-2(1H)-one
CAS No: 22462-34-6
Molecular Formula: C4H2ClFN2O
Molecular Weight: 148.5
CAT No: ALL-A07551
Keywords: O=C1N=CC(F)=C(Cl)N1
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY 45
Chemical Name: Bis(5-fluoro-4-(4-fluoro-1-isopropyl-2-...
CAS No: N.A.
Molecular Formula: C30H27F4N9
Molecular Weight: 589.6
CAT No: ALL-A07552
Keywords: CC1=NC2=C(F)C=C(C3=NC(NC4=NC=C(F)C(C5=CC...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB IMPURITY DP1
Chemical Name: 1-Ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-i...
CAS No: N.A.
Molecular Formula: C27H32F2N8O
Molecular Weight: 522.6
CAT No: ALL-A07553
Keywords: CC(C)N1C2=CC(C3=NC(NC4=CC=C(C=N4)CN5CCN(...
Inventory Status:3-4 WEEK
ABEMACICLIB NITROSO IMPURITY 10
Chemical Name: N-(5-((4-ethylpiperazin-1-yl)methyl)pyri...
CAS No: N.A.
Molecular Formula: C23H22F2N10O2
Molecular Weight: 508.5
CAT No: ALL-A07555
Keywords: CCN(CC1)CCN1CC(C=N2)=CC=C2N(N=O)C3=NC=C(...
Inventory Status:DELIVERY 3-4 WEEKS
ABEMACICLIB NITROSO IMPURITY 7
Chemical Name: (4-Fluoro-2-methyl-1-nitroso-1H-benzo[d]...
CAS No: N.A.
Molecular Formula: C8H7BFN3O3
Molecular Weight: 223.0
CAT No: ALL-A07557
Keywords: OB(C1=CC(F)=C2C(N(N=O)C(C)=N2)=C1)O
Inventory Status:DELIVERY 3-4 WEEKS